Open AccessBupivacaine at clinically relevant concentrations induces toxicity in human intervertebral disc cells via the induction of autophagy in vitro
Author(s) -
Ge Yang,
Zhuoyang Li,
Haibo Mei,
Weihua Ye,
Scott C.-H. Huang,
Liu K,
Qian Tan
Publication year - 2019
Publication title -
molecular medicine reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 56
eISSN - 1791-3004
pISSN - 1791-2997
DOI - 10.3892/mmr.2019.10279
Subject(s) - autophagy , pi3k/akt/mtor pathway , bupivacaine , protein kinase b , apoptosis , microbiology and biotechnology , cytotoxicity , autophagosome , pharmacology , biology , chemistry , in vitro , signal transduction , biochemistry