Open AccessAssociation of HNF4α gene polymorphisms with susceptibility to type 2 diabetes
Author(s) -
Ruicheng Ma,
Hongjiang Yang,
Jingfang Li,
Xu Yang,
Xiaohong Chen,
Yan Hu,
Zhou Wang,
Xue Li,
Wei Zhou
Publication year - 2016
Publication title -
molecular medicine reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 56
eISSN - 1791-3004
pISSN - 1791-2997
DOI - 10.3892/mmr.2016.4780
Subject(s) - single nucleotide polymorphism , haplotype , genetics , type 2 diabetes , genotype , biology , population , allele frequency , type 2 diabetes mellitus , allele , diabetes mellitus , gene , medicine , endocrinology , environmental health
The present study aimed to explore the association between single nucleotide polymorphisms (SNPs) in the hepatocyte nuclear factor‑4α (HNF‑4α) gene and the incidence of type 2 diabetes in the Chinese Bai population in Dali city, China. The polymerase chain reaction‑restriction fragment length polymorphism method was used to analyze four SNPs (rs4810424, rs1884613, rs1884614 and rs2144908) in the HNF‑4α gene in 44 patients with type 2 diabetes and 87 healthy controls in Chinese Bai individuals. The haploid type was subsequently built to assess its association with the incidence of type 2 diabetes in the Bai population in Dali city. No significant differences were observed between the genotype and allele frequencies of the four SNPs in the HNF‑4α gene and type 2 diabetes mellitus (P>0.05). However, the frequency of haplotype, CCTA, built by rs4810424, rs1884613, rs1884614 and rs2144908 was significantly higher in the type 2 diabetes mellitus group compared with the control group (χ2=8.34, P=0.004). The four polymorphisms, rs4810424, rs1884613, rs1884614 and rs2144908, in the HNF‑4α gene were not the susceptible loci for type 2 diabetes in the Bai population of Dali city, however, the haplotype, CCTA, built from the four SNPs may increase the risk of type 2 diabetes in this population.