Open AccessMiliary lung metastases from ROS1‑rearranged lung adenocarcinoma: A case report
Author(s) -
Ryota Otoshi,
Akimasa Sekine,
Koji Okihara,
Takuma Katano,
Masato Asaoka,
Satoshi Ikeda,
Tomohisa Baba,
Shigeru Komatsu,
Eri Hagiwara,
Takashi Ogura
Publication year - 2020
Publication title -
molecular and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 7
eISSN - 2049-9469
pISSN - 2049-9450
DOI - 10.3892/mco.2020.2040
Subject(s) - adenocarcinoma , lung , medicine , ros1 , lung cancer , adenocarcinoma of the lung , pathology , metastasis , oncology , cancer
Miliary lung metastases are a rare form of metastasis of non-small-cell lung carcinoma. Miliary lung metastases commonly develop in lung adenocarcinoma with epidermal growth factor receptor mutation. In the present study, we present a case of miliary lung metastases from lung adenocarcinoma with ROS1 rearrangement. The patient, who had a history of surgery for stage IIIA lung adenocarcinoma, presented to our hospital with cough, dyspnea, and severe hypoxia. Chest computed tomography showed numerous tiny, randomly distributed nodules throughout both lungs. No metastases were observed in other organs. Molecular profiling of the surgical specimens was positive for ROS1 rearrangement. The results suggest that chest physicians should be aware that miliary lung metastases can develop in patients with lung adenocarcinoma with ROS1 rearrangement.