Open AccessPrimary tumor SUVmax on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy
Author(s) -
Shusuke Yagi,
Tetsutaro Yahata,
Yasushi Mabuchi,
Yuko Tanizaki,
Aya Kobayashi,
Michihisa Shiro,
Nakao Ota,
Sawako Minami,
Masaki Tomita,
Kazuhiko Ino
Publication year - 2016
Publication title -
molecular and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 7
eISSN - 2049-9469
pISSN - 2049-9450
DOI - 10.3892/mco.2016.953
Subject(s) - medicine , standardized uptake value , cervical cancer , stage (stratigraphy) , primary tumor , positron emission tomography , radical hysterectomy , lymphadenectomy , receiver operating characteristic , hysterectomy , cancer , lymph node , radiology , metastasis , nuclear medicine , oncology , paleontology , biology
The objective of the present study was to investigate the prognostic value of 18 F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV max ) of the primary tumor was measured, and the association between the SUV max and clinicopathological factors or patient outcomes was analyzed. The SUV max was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV max were significantly lower compared with patients with a low SUV max , using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV max were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV max of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV max on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV max of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer.