Open AccessETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review)
Author(s) -
Zaki Shaikhibrahim,
Nicolas Wernert
Publication year - 2012
Publication title -
international journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.405
H-Index - 122
ISSN - 1019-6439
DOI - 10.3892/ijo.2012.1380
Subject(s) - ets transcription factor family , biology , prostate cancer , angiogenesis , transcription factor , cancer research , oncogene , cell cycle , cancer , prostate , cell , gene , genetics
The ETS family of transcription factors is known to play important roles in various biological processes such as development, differentiation, proliferation, apoptosis, migration, tissue remodeling, invasion and angiogenesis in various cell types including B cells, endothelial cells, fibroblasts as well as diverse neoplastic cells. In prostate cancer, recurrent gene fusions involving members of the ETS family are frequently reported. ETS-1, the prototype of the ETS family, is expressed in different cell types and is known to play various roles during both physiological and pathological conditions. In this review, we focus on studies investigating the role of ETS-1 in prostate cancer.