Open AccessEvaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer
Author(s) -
Yuji Toiyama,
Hiroyuki Fujikawa,
Mikio Kawamura,
Kohei Matsushita,
Susumu Saigusa,
Koji Tanaka,
Yasuhiro Inoue,
Keiji Uchida,
Yasuhiko Mohri,
Masato Kusunoki
Publication year - 2011
Publication title -
international journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.405
H-Index - 122
ISSN - 1019-6439
DOI - 10.3892/ijo.2011.1247
Subject(s) - colorectal cancer , metastasis , cxcl10 , stage (stratigraphy) , cancer , medicine , pathological , gastroenterology , oncology , oncogene , cytokine , molecular medicine , pathology , biology , chemokine , inflammation , cell cycle , paleontology
The aim of this study was to identify novel and reliable serum markers relatedto the prognosis of colorectal cancer (CRC) patients and to assess the associationbetween selected markers and clinical outcome. We performed experiments usingcytokine arrays to investigate the cytokine profiles in serum from stage IV CRCpatients, compared with those of stage I patients. Serum CXCL10 was measured usingan ELISA in 218 CRC patients and 17 normal volunteers to clarify the associationof CXCL10 with clinical outcome. The mean serum CXCL10 concentration in CRC patientswas significantly higher compared to that in normal volunteers. Serum CXCL10 levelsincreased significantly in accordance with the progression of UICC stage classification.Serum CXCL10 was significantly associated with high pathological T stage, thepresence of vascular invasion and distant metastasis. Elevated serum CXCL10 levelswere significantly associated with poor survival in all stages or in stage I-IIIwith curative patients, respectively, and were an independent marker in predictingliver metastasis. Immunohistochemical analysis showed that CXCL10 was expressedin cancer cells at primary tumor and liver metastases sites, and in normal livertissue surrounding metastatic cancer cells. Comprehensive analysis using cytokinearrays identified the novel serum prognosis marker CXCL10. Preoperative high serumlevels of CXCL10 were associated with poor prognosis and liver metastasis in CRC.