Open AccessFibroblast growth factor-23 may serve as a novel biomarker for renal osteodystrophy progression
Author(s) -
Si Yan Liu,
Dong Dong Zhang,
Yang Wu,
Huang Huang Luo,
Guang Mei Jiang,
Yao Xu,
Yue Wu,
Xun Xia,
Wei Wei,
Bo Hu,
Peng Hu
Publication year - 2018
Publication title -
international journal of molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.048
H-Index - 90
eISSN - 1791-244X
pISSN - 1107-3756
DOI - 10.3892/ijmm.2018.3934
Subject(s) - fibroblast growth factor 23 , renal osteodystrophy , biomarker , fibroblast growth factor , osteoid , medicine , nephrectomy , endocrinology , chemistry , calcium , parathyroid hormone , kidney , kidney disease , biochemistry , receptor
The purpose of the present study was to determine whether fibroblast growth factor (FGF)‑23 could serve as a novel biomarker for renal osteodystrophy (ROD) progression. A rat model of ROD was induced by left nephrectomy plus intravenous injection of Adriamycin. Serum FGF‑23 was determined using an enzyme‑linked immunosorbent assay. Serum level and bone expression of FGF‑23 were both significantly elevated in the ROD group at 24 h post‑surgery. Serum FGF‑23 was negatively correlated with calcium, phosphate, 25‑hydroxyvitamin D, conventional bone biomarkers and bone collagen X. More importantly, serum FGF‑23 was significantly associated with abnormalities in bone formation rate, osteoblasts, osteoclasts, trabecular volume thickness and osteoid volume. Therefore, FGF‑23 may serve as a novel biomarker for ROD.