Open AccessMicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway
Author(s) -
Yun Zhang,
Shaochen Xu,
L. Eric Huang,
Haichao Zhou,
Bing Li,
Chenni Shao,
Yunfeng Yang
Publication year - 2018
Publication title -
international journal of molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.048
H-Index - 90
eISSN - 1791-244X
pISSN - 1107-3756
DOI - 10.3892/ijmm.2018.3551
Subject(s) - pten , pi3k/akt/mtor pathway , protein kinase b , downregulation and upregulation , cancer research , microrna , chondrocyte , cell growth , wortmannin , signal transduction , microbiology and biotechnology , apoptosis , chemistry , biology , cartilage , biochemistry , anatomy , gene
The function of microRNA‑130a in development and progression of osteoarthritis was determined. In osteoarthritis patients, the serum levels of microRNA‑130a were decreased, compared with normal group. Overexpression of microRNA‑130a increased cell proliferation and decreased apoptosis of chondrocytes, and downregulation of microRNA‑130a also decreased cell proliferation and induced apoptosis in chondrocytes. Downregulation of microRNA‑130a promoted Bax and caspase‑3/9 protein expression, increased inflammation divisors and suppressed the PTEN/PI3K/Akt signaling pathway. PTEN inhibitor, VO‑Ohpic trihydrate increased the destructive effect of microRNA‑130a on cell proliferation of chondrocytes. PI3K inhibitor, wortmannin also increased the destructive effect of microRNA‑130a on osteoarthritis. In conclusion, microRNA‑130a is an important regulator of osteoarthritis in chondrocytes through PTEN/PI3K/Akt signaling pathway.