Open AccessTrop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction
Author(s) -
Jianye Yang,
Yuan Zhou,
Bo Liu,
Hongfei Wang,
Xiaona Du
Publication year - 2013
Publication title -
international journal of molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.048
H-Index - 90
eISSN - 1791-244X
pISSN - 1107-3756
DOI - 10.3892/ijmm.2013.1332
Subject(s) - myocardial infarction , cell cycle , oncogene , apoptosis , molecular medicine , cell growth , kinase , cancer research , cell , function (biology) , mitogen activated protein kinase , medicine , cardiac function curve , protein kinase a , microbiology and biotechnology , biology , heart failure , biochemistry
Trop2 is a cell-surface glycoprotein associated with epithelial carcinomas. Although recent studies indicated that Trop2 is expressed in some stem-like cells, the molecular function of the protein remains largely unknown. In the present study, we observed that acute phase myocardial infarction (MI) induced an increase of c-kit+/Trop2+ cells and found that Trop2 enhanced cardiac c-kit+ cell survival and proliferation via its antiapoptotic activity, due to an elevated activity of ribosomal S6 kinases in the mitogen-activated protein kinase pathway. This study provides insight into better understanding the molecular function of Trop2, which could serve as a potential target for the treatment of MI.