Open AccessMaternal inherited thrombophilia and pregnancy outcomes
Author(s) -
Diana Voicu,
Octavian Munteanu,
Florentina Gherghiceanu,
Luciana Arsene,
Roxana Elena Bohîlţea,
Delia Maria Gradinaru,
Monica Mihaela Cîrstoiu
Publication year - 2020
Publication title -
experimental and therapeutic medicine
Language(s) - English
Resource type - Journals
eISSN - 1792-1015
pISSN - 1792-0981
DOI - 10.3892/etm.2020.8747
Subject(s) - thrombophilia , preeclampsia , medicine , intrauterine growth restriction , pregnancy , obstetrics , factor v leiden , methylenetetrahydrofolate reductase , gynecology , thrombosis , gestation , venous thrombosis , genetics , biology , gene , genotype
Thrombophilia is a group of genetical disorders that cause blood to clot abnormally. Thrombophilia is linked to recurrent pregnancy loss, foetal growth restriction, late miscarriages, stillbirth and preeclampsia. Clinicians usually apply the term thrombophilia only to patients with atypical thrombosis. A successful outcome of pregnancy requires an efficient uteroplacental circulation. Since this system may be compromised by disorders associated with a prothrombotic state, it was postulated that maternal thrombophilia might be a risk factor for preeclampsia and intrauterine growth retardation. The study included 459 pregnant women with gestational ages ranging from 14 weeks to 28 weeks and the patients in the study were tested for hereditary thrombophilia. The type of thrombophilic mutation most common found was the MTHFR mutation (25.7%), followed by the prothrombin gene mutation (20.9%) and the Leiden factor V mutation (15.7%). Also 15.03% patients had been diagnosed with preeclampsia and 6.75% of the pregnant women had IUGR fetuses.