Open AccessTumor suppressor miR-211-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma
Author(s) -
Yifan Li,
Lü Jin,
Duqun Chen,
Jiajü Lü,
Zhengming Su,
Shangqi Yang,
Yaoting Gui,
Xiangming Mao,
Guohui Nie,
Yongqing Lai
Publication year - 2018
Publication title -
experimental and therapeutic medicine
Language(s) - English
Resource type - Journals
eISSN - 1792-1015
pISSN - 1792-0981
DOI - 10.3892/etm.2018.5908
Subject(s) - oncogene , apoptosis , suppressor , cell cycle , renal cell carcinoma , cancer research , cell growth , molecular medicine , cell , a431 cells , cancer , biology , microbiology and biotechnology , medicine , oncology , genetics
Increasing evidence has demonstrated that microRNA (miRNA) serve an important role in the tumorigenesis of various types of cancer, such as renal cell carcinoma (RCC). The expression of miR-211-5p has been detected in RCC tissue by microarray profiling. However, studies regarding miR-211-5p and RCC remain rare. In the present study, the expression of miR-211-5p in RCC tissues and cell lines was revealed to be downregulated by reverse transcription-quantitative polymerase chain reaction analyses. The present results also revealed that the upregulation or downregulation of miR-211-5p inhibited or promoted, respectively, RCC cell proliferation, migration and invasion. In addition, the upregulation or downregulation of miR-211-5p induced or inhibited, respectively, RCC cell apoptosis. However, the present study only identified that downregulation of miR-211-5p promoted 786O and ACHN cell viability. The above results suggest that miR-211-5p may be a tumor suppressor in the tumorigenesis of RCC and may be a potential therapeutic target for RCC in the future. Further research should focus on the underlying mechanism of miR-211-5p in RCC and on investigating the possible use of miR-211-5p as a biomarker for RCC.