Open AccessIncremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease
Author(s) -
Youjing Sun,
Fang Wang,
Ruisheng Zhang,
Haiyan Wang,
Chenguang Yang,
Jie Cai,
WeiEr Zang,
MingZhou Li,
Xin Qi,
Jing Li
Publication year - 2015
Publication title -
experimental and therapeutic medicine
Language(s) - English
Resource type - Journals
eISSN - 1792-1015
pISSN - 1792-0981
DOI - 10.3892/etm.2015.2435
Subject(s) - coronary artery disease , receiver operating characteristic , cardiology , speckle tracking echocardiography , medicine , cad , area under the curve , coronary angiography , stage (stratigraphy) , speckle pattern , myocardial infarction , ejection fraction , biology , artificial intelligence , computer science , biochemistry , heart failure , paleontology
The aim of the present study was to investigate the incremental value of resting three-dimensional speckle-tracking echocardiography (3D-STE) in the detection of early-stage left ventricular dysfunction in patients with coronary artery disease (CAD). A total of 110 patients suspected of having CAD were recruited. All patients underwent 3D-STE and coronary artery angiography (CAG). They were divided to a CAD group and a normal group according to the results of CAG. Using 3D-STE software, the peak values of longitudinal strain (LS), circumferential strain (CS), radial strain (RS) and area strain (AS) and the time to peak value of these strains (T-LS, T-CS, T-RS and T-AS) were measured. A receiver operator characteristic curve (ROC) was used to analyze the sensitivity of these strains for the diagnosis of CAD. ROC analysis indicated that T-LS and composite indices combining the peak strain value and time to peak of LS, CS and AS have diagnostic value for the early detection of CAD; the area under the curve (AUC) values were 0.667, 0.692, 0.621 and 0.672 respectively (P<0.005). The composite index of longitudinal strain demonstrated the highest diagnostic value for CAD with 62% sensitivity and 76% specificity. These results indicate that 3D-STE has incremental value for the diagnosis of CAD in patients at rest.