Open AccessEpigenetic modulation during hippocampal development (Review)
Author(s) -
SiJing Fan,
Anbang Sun,
Lian Liu
Publication year - 2018
Publication title -
biomedical reports
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 25
eISSN - 2049-9442
pISSN - 2049-9434
DOI - 10.3892/br.2018.1160
Subject(s) - epigenetics , hippocampal formation , dentate gyrus , neuroscience , dna methylation , hippocampus , histone , biology , epigenetic regulation of neurogenesis , psychology , genetics , dna , gene expression , histone methyltransferase , gene
The hippocampus is located in the limbic system and is vital in learning ability, memory formation and emotion regulation, and is associated with depression, epilepsy and mental retardation in an abnormal developmental situation. Several factors have been found to modulate the development of the hippocampus, and epigenetic modification have a crucial effect in this progress. The present review summarizes the epigenetic modifications, including DNA methylation, histone acetylation, and non-coding RNAs, regulating all stages of hippocampal development, focusing on the growth of Ammons horn and the dentate gyrus in humans and rodents. These modifications may significantly affect hippocampal development and health in addition to cognitive processes.