z-logo
open-access-imgOpen Access
Protein kinase CK2 in development and differentiation
Author(s) -
Claudia Götz,
Mathias Montenarh
Publication year - 2016
Publication title -
biomedical reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 25
eISSN - 2049-9442
pISSN - 2049-9434
DOI - 10.3892/br.2016.829
Subject(s) - casein kinase 2 , microbiology and biotechnology , biology , cellular differentiation , cyclin dependent kinase 4 , casein kinase 1 , embryonic stem cell , ask1 , protein kinase a , map2k7 , cyclin dependent kinase 2 , kinase , biochemistry , gene
Among the human kinomes, protein kinase CK2 (formerly termed casein kinase II) is considered to be essential, as it is implicated in the regulation of various cellular processes. Experiments with pharmacological inhibitors of the kinase activity of CK2 provide evidence that CK2 is essential for development and differentiation. Therefore, the present review addresses the role of CK2 during embryogenesis, neuronal, adipogenic, osteogenic and myogenic differentiation in established model cell lines, and in embryonic, neural and mesenchymal stem cells. CK2 kinase activity appears to be essential in the early stages of differentiation, as CK2 inhibition at early time points generally prevents differentiation. In addition, the present review reports on target proteins of CK2 in embryogenesis and differentiation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here