Open AccessPleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer
Author(s) -
María Aparecida Nagai
Publication year - 2016
Publication title -
biomedical reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 25
eISSN - 2049-9442
pISSN - 2049-9434
DOI - 10.3892/br.2016.580
Subject(s) - pleckstrin homology domain , biology , mediator , oncogene , transcription factor , homology (biology) , genetics , cell cycle , signal transduction , inhibitor of apoptosis domain , gene , microbiology and biotechnology , apoptosis , computational biology , programmed cell death , caspase
Pleckstrin homology-like domain, family A, member 1 ( PHLDA1 ) encodes a member of an evolutionarily conserved pleckstrin homology-related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of PHLDA1 remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.