Open AccessAssociation between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis
Author(s) -
Jing Lian,
Peiliang Fang,
Dongjun Dai,
Yanna Ba,
Yang Xi,
Xiaoyan Huang,
Junxin Li,
Xiaoliang Chen,
Jian Guo,
Feng Guan,
Ping Peng,
Ruochi Zhao,
Shangshi Zhang,
Fang Gao,
Linlin Tang,
Cheng Zhang,
Huihui Ji,
Qingxiao Hong,
Huadan Ye,
Limin Xu,
Qilong Zhong,
Panpan Li,
Jian Zhou,
Shiwei Duan
Publication year - 2014
Publication title -
biomedical reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 25
eISSN - 2049-9442
pISSN - 2049-9434
DOI - 10.3892/br.2014.325
Subject(s) - coronary artery disease , odds ratio , meta analysis , confidence interval , medicine , case control study , cad , oncology , gastroenterology , immunology , biology , biochemistry
Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 ( LGALS2 ) is involved in the cytokine lymphotoxin-α (LTA) cascade that may influence the progress of CAD. The aim of the present study was to assess the association between the LGALS2 3279C>T (rs7291467) polymorphism and CAD. A total of 562 cases and 572 controls were recruited to examine the association. A systematic meta-analysis was performed to evaluate the contribution of LGALS2 3279C>T polymorphism to the risk of CAD among 12,093 cases and 11,020 controls. There was no significant association found in the present case-control study. However, the meta-analysis showed that LGALS2 3279C>T played a protective role in CAD [P=0.008, odds ratio (OR), 0.90; 95% confidence interval (95% CI), 0.82-0.97] and particularly in the Asian population (P=0.006; OR, 0.82; 95% CI, 0.71-0.94). The present case-control study did not find a significant association between LGALS2 3279C>T and CAD in the Eastern Han Chinese population. However, the meta-analysis indicated that LGALS2 3279C>T played a protective role in CAD, suggesting an ethnic difference in the association of the locus with CAD.