Open AccessPolymorphisms of DRD2 and DRD3 genes and Parkinson’s disease: A meta-analysis
Author(s) -
Dongjun Dai,
Yunliang Wang,
Lingyan Wang,
Jinfeng Li,
Qingqing Ma,
Jianmin Tao,
Xingyu Zhou,
Hanlin Zhou,
Yi Jiang,
Guanghui Pan,
Limin Xu,
Ping Ru,
Danfeng Lin,
Jun Pan,
Xu Liu,
Meng Ye,
Shiwei Duan
Publication year - 2014
Publication title -
biomedical reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.607
H-Index - 25
eISSN - 2049-9442
pISSN - 2049-9434
DOI - 10.3892/br.2014.220
Subject(s) - odds ratio , parkinson's disease , medicine , dopamine receptor d3 , polymorphism (computer science) , oncology , haplotype , allele , dopamine receptor d2 , confidence interval , meta analysis , genetics , biology , endocrinology , disease , dopamine , gene
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects ~2% of the population aged ≥65 years. The degeneration of dopamine neurons in the substantia nigra contributes to the pathogenesis of PD. Dopamine receptor D2 ( DRD2) and dopamine receptor D3 ( DRD3) are two key subtypes of dopamine receptors. The aim of our study was to evaluate the association between the polymorphisms of DRD2 and DRD3 genes and PD. Meta-analyses were conducted from 16 studies (46 stages) among 4,279 cases and 5,661 controls between PD and 9 polymorphisms ( DRD2 : rs1800497, rs1079597, rs6278, rs6279, rs273482, rs1799732 and rs1076563; DRD3 : rs6280 and rs2134655). A significant association was observed between DRD3 rs2134655 polymorphism and PD [P=0.01, odds ratio (OR)=1.17, 95% confidence interval (CI): 1.03-1.32] and a borderline association was observed between DRD2 rs1800497 polymorphism and PD in Europeans (P=0.05, OR=1.13, 95% CI: 1.00-1.27). Findings of the current meta-analysis suggested that DRD3 rs2134655 polymorphism was associated with a 17% increased risk of PD and that DRD2 rs1800497 polymorphism had a potential to increase the risk of PD by 13% in Europeans. Future large-scale studies are required to confirm the ethnic difference of DRD2 rs1800497 polymorphism and to determine whether there were significant associations of PD with other polymorphisms in DRD2 and DRD3 genes.