Open AccessQuantitative EEG Correlates with NIHSS and MoCA for Assessing the Initial Stroke Severity in Acute Ischemic Stroke Patients
Author(s) -
Ahmad Asmedi,
Abdul Gofir,
Sekar Satiti,
Paryono Paryono,
Ditha Praritama Sebayang,
Dyanne Paramita Arindra Putri,
Amelia Nur Vidyanti
Publication year - 2022
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2022.8483
Subject(s) - medicine , montreal cognitive assessment , stroke (engine) , confounding , acute stroke , cardiology , ischemic stroke , correlation , electroencephalography , physical therapy , cognitive impairment , ischemia , disease , psychiatry , mechanical engineering , geometry , mathematics , tissue plasminogen activator , engineering
BACKGROUND: National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) measure stroke severity by assessing the functional and cognitive outcome, respectively. However, they cannot be used to measure subtle evolution in clinical symptoms during the early phase. Quantitative EEG (qEEG) can detect any subtle changes in CBF and brain metabolism thus may also benefit for assessing the severity. AIM: This study aims to identify the correlation between qEEG with NIHSS and MoCA for assessing the initial stroke severity in acute ischemic stroke patients.METHODS: This was a cross-sectional study. We recruited 30 patients with first-ever acute ischemic stroke hospitalized in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. We measured the NIHSS, MoCA score, and qEEG parameter during the acute phase of stroke. Correlation and regression analysis was completed to investigate the relationship between qEEG parameter with NIHSS and MoCA.RESULTS: Four acute qEEG parameter demonstrated moderate-to-high correlations with NIHSS and MoCA. DTABR had positive correlation with NIHSS (r = 0.379, p = 0.04). Meanwhile, delta-absolute power, DTABR, and DAR were negatively correlated with MoCA score (r = −0.654, p = 0.01; r = −0.397, p = 0.03; and r = −0.371, p = 0.04, respectively). After adjusted with the confounding variables, delta-absolute power was independently associated with MoCA score, but not with NIHSS (B = −2.887, 95% CI (−4.304–−1.470), p < 0.001).CONCLUSIONS: Several qEEG parameters had significant correlations with NIHSS and MoCA in acute ischemic stroke patients. The use of qEEG in acute clinical setting may provide a reliable and efficient prediction of initial stroke severity. Further cohort study with larger sample size and wide range of stroke severity is still needed.