Open AccessFormulation of Orally Disintegrating Tablets of Captopril as Superdisintegrant using Corncob (Zea mays L.)
Author(s) -
Gabena Indrayani Dalimunthe,
Samran Samran,
Najarul Susanto,
Ridwanto Ridwanto,
Kasta Gurning
Publication year - 2022
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2022.8343
Subject(s) - microcrystalline cellulose , corncob , medicine , captopril , cellulose , chromatography , raw material , organic chemistry , chemistry , blood pressure
AIM: This study aimed to make corncobs the basic material for the manufacture of microcrystalline cellulose.METHODS: Manufacture of corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield of CCMs of 14.51% can be used as orally disintegrating tablet (ODT) and has similarities with Avicel as standard comparison.RESULTS: Both organoleptic results were pH 5.6 and 6.54; drying shrinkage 3.33% and 4.39%; total ash content 0.17% and 0.02%; and water solubility 0.9% and 0.12%. Furthermore, the real specific gravity is 0.317 and 0.306 g/cm3, incompressible density is 0.379 and 0.375 g/cm3, the true density is 1.291 and 1.206 g/cm3, Hausner index is 1.195 and 1.225, compressibility index is 19.55 and 22.55%, and porosity is 75.5 and 74.6%.CONCLUSION: Captopril ODT tablet preparations with CCM as filler have almost the exact tablet evaluation results compared to Avicel and to meet the requirements.