Open AccessHolothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections
Author(s) -
Sri Handayani,
Nurdiaurdiana,
Sri Winarsih,
Agustina Tri Endharti
Publication year - 2022
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2022.8086
Subject(s) - antifungal , candida albicans , sea cucumber , antifungal drugs , minimum inhibitory concentration , medicine , microbiology and biotechnology , in silico , corpus albicans , pharmacology , biology , biochemistry , antimicrobial , ecology , gene
BACKGROUND: The previous studies have identified chemical compounds in sea cucumbers that have antifungal properties. However, further information on the underlying antifungal needed to be updated.AIM: This study aimed to discover efficient antifungal treatments against candidiasis disease.MATERIALS AND METHODS: This study analyzed the antifungal activity from Holothurin against Candida albicans in silico using molecular docking and minimum inhibitory concentration (MIC).RESULTS: The results revealed that holothurin has a binding affinity of −7.9 kcal/mol and MIC value of 1.5 mg/ml.CONCLUSION: Holothurin may inhibit the infection of C. albicans. Furthermore, additional research is required to validate the activity of this compound.