Holothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections | Zendy

Sri Handayani | Zendy; Nurdiaurdiana | Zendy; Sri Winarsih | Zendy; Agustina Tri Endharti | Zendy

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Holothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections

Author(s) -

Sri Handayani,

Nurdiaurdiana,

Sri Winarsih,

Agustina Tri Endharti

Publication year - 2022

Publication title -

open access macedonian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.288

H-Index - 17

ISSN - 1857-9655

DOI - 10.3889/oamjms.2022.8086

Subject(s) - antifungal , candida albicans , sea cucumber , antifungal drugs , minimum inhibitory concentration , medicine , microbiology and biotechnology , in silico , corpus albicans , pharmacology , biology , biochemistry , antimicrobial , ecology , gene

BACKGROUND: The previous studies have identified chemical compounds in sea cucumbers that have antifungal properties. However, further information on the underlying antifungal needed to be updated.AIM: This study aimed to discover efficient antifungal treatments against candidiasis disease.MATERIALS AND METHODS: This study analyzed the antifungal activity from Holothurin against Candida albicans in silico using molecular docking and minimum inhibitory concentration (MIC).RESULTS: The results revealed that holothurin has a binding affinity of −7.9 kcal/mol and MIC value of 1.5 mg/ml.CONCLUSION: Holothurin may inhibit the infection of C. albicans. Furthermore, additional research is required to validate the activity of this compound.

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