Open AccessOutcome Analysis and Prognostic Factors in Patients of Glioblastoma Multiforme: An Indonesian Single Institution Experience
Author(s) -
Sudibio Sudibio,
J.L. Monroy Antón,
Handoko Handoko,
Tiara Bunga Mayang Permata,
Henry Kodrat,
Endang Nuryadi,
Henry Riyanto Sofyan,
Rahmad Mulyadi,
Renindra Ananda Aman,
Soehartati Gondhowiardjo
Publication year - 2021
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2021.7502
Subject(s) - medicine , univariate analysis , glioblastoma , multivariate analysis , gastroenterology , radiation therapy , stage (stratigraphy) , oncology , adjuvant therapy , chemotherapy , paleontology , cancer research , biology
Aims: This study was done to assess the survival of patients with glioblastoma multiform and to identify factors that can affect patient survival.
Materials and methods: From January 2015 to December 2019, 55 patients with histopathologically confirmed glioblastoma multiform and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed.
Results: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs >50 years, p=0.02), performance status (≥90 vs 70-80 vs 20.4cm3, p=0.001) and time to initiate adjuvant therapy ( 6 weeks, p=0.01) were significantly affect overall survival. In multivariate analysis, RTOG RPA classification and involvement of parietal lobes were independent prognostic factors for overall survival.
Conclusions: RTOG RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients.