Open AccessSunkist Peel Ethanol Extract Ameliorates Diabetic Nephropathy in Streptozotocin-Induced Diabetic Wistar Rats
Author(s) -
M. Yusuf Sari,
Chrismis Novalinda Ginting,
OK Yulizal
Publication year - 2021
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2021.7362
Subject(s) - medicine , diabetic nephropathy , creatinine , diabetes mellitus , streptozotocin , nephropathy , kidney , analysis of variance , ethanol , kidney disease , traditional medicine , endocrinology , biochemistry , chemistry
Background: Kidney disorders in diabetic patients can gradually fall into end-stage kidney disease (ESKD) which can greatly interfere with the person's quality of life, in developed countries about 50% of patients with ESKD are caused by diabetes. On the other hand, various studies on citrus fruits have been performed to explore its pharmacological benefits.
Aim: this study was aimed to explore the benefits of Sunkist orange peel ethanol extract against diabetic nephropathy in wistar rats as animals’ trial.
Methods: This study was used 25 rats and was divided into five groups: viz. control, standard, Sunkist Peel Ethanol Extract-I, II, and III (500, 750, and 1500 mg/kg BW). After 28 days of intervention, BUN and Creatinine levels were measured in all rats. Meanwhile, data analysis used is parametric statistics in the form of One-Way ANOVA with alternative analysis in the form of the Kruskal Wallis test.
Results: This study showed that the Sunkist peels ethanol extract significantly decreased BUN (P-Value < 0.05) and creatinine (P-Value < 0.05) level. The highest dosage of extract did not show a significant difference in BUN level against standard group.
Conclusion: Overall, it can be concluded that the Sunkist peel ethanol extract has kidney protection effect against diabetic nephropathy at highest dosage (1500 mg/ kg BW).