Open AccessThe Effectiveness of Lumbricus rubellus Extract Toward Interleukin-10 and Immunoglobulin E and Atopic Dermatitis Scoring Index (SCORAD)
Author(s) -
Farida Tabri,
Pipim Septiana Bayasari,
Rosani Sri Camelia Nurdin,
Anis Irawan Anwar,
Anni Adriani,
Farida Ilyas
Publication year - 2021
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2021.7196
Subject(s) - medicine , scorad , lumbricus rubellus , atopic dermatitis , immunoglobulin e , interleukin , gastroenterology , antibody , immunology , dermatology life quality index , disease , cytokine , earthworm , paleontology , biology
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by severe pruritic symptoms and chronic AD related to clinical features in form of lichenification associated with a history of atopic disease both for himself and family.AIM: This study aims to determine the effectiveness of using earthworm extract (Lumbricus rubellus) to increase interleukin (IL)-10 and decrease immunoglobulin E (IgE), and to describe the AD (SCORAD) scoring index of patients with AD.METHODS: This research used quantitative with quasi experiment method. The data were analyzed using SPSS v19 program. To determine the basic characteristics of numerical variables, the mean standard deviation is functioned if the data distribution amount is even, if it is not, it used the median. Meanwhile, to observe the relationship between L. rubellus extract and IgE, Mann-Whitney test analysis (U-Test) was used.RESULTS: The results of this study indicate that the administration of L. rubellus extract showed a changes and differences before and after being involved with the extract. IgE levels between ERL and no ERL groups had differences (p < 0.05), however on day 15 both groups did not show any differences. Meanwhile, the SCORAD index indicated that the influence of lumbricus rebellus extract has an effect on low number of AD patients.CONCLUSION: It can be concluded that the administration of L. rubellus extract in patients with AD is quite effective.