Open AccessAmelioration of Cisplatin-induced Liver Injury by Extract Ethanol of Pometia pinnata
Author(s) -
Adrian Adrian,
Rony Abdi Syahputra,
Sukirman Lie,
Sony Eka Nugraha
Publication year - 2021
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2021.6785
Subject(s) - medicine , lactate dehydrogenase , cisplatin , ethanol , alkaline phosphatase , liver injury , pharmacology , traditional medicine , alanine aminotransferase , biochemistry , enzyme , chemistry , chemotherapy
BACKGROUND: Cisplatin use in clinical practice has been associated with an increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, and lactate dehydrogenase (LDH).AIM: The aim of this study is to determine the hepatoprotective activity of extract ethanol Pometia pinnata on rats induced Cisplatin.MATERIALS AND METHODS: Thirty rats were separated into six groups (five rats). Group I was received only carboxy methyl cellulose. Group II was received a 7 mg/kgbw Cisplatin injection on day 3. Group III-VI were extract groups (Vitamin C 1%, 100 mg/kgbb, 200 mg/kgbb, and 400 mg/kgbb) administered orally from day 1 to 7, followed by Cisplatin injection on day 3. On day 8, rats were injected with 1% ketamine, open the chest and draw blood directly from the heart and centrifugated 5000 RPM (10–15 min), take the supernatant layer for analysis AST, ALT, total protein, and LDH levels.RESULTS: The effect of extract ethanol of P. pinnata on liver injury biochemical markers AST, ALT, LDH, and total protein. Group negative had a significant increase (p 0.05) that showing P. pinnata extract has hepatoprotective activity.CONCLUSION: In summary, extract ethanol of P. pinnata has hepatoprotective effect by reducing the level of AST, ALT, total protein, and LDH levels.