Open AccessEffect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil
Author(s) -
Maha A. Al-Sammak
Publication year - 2021
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2021.6207
Subject(s) - cadmium chloride , medicine , saline , cadmium , body weight , lung , physiological saline , intratracheal instillation , adult male , pathology , bronchoalveolar lavage , chemistry , organic chemistry
This study is to detect the toxic effect of cadmium chloride on the histological structure of the lung and the effect of parsley oil to amilorate these changes
In this experiement 40 adult male mice were divided into four groups. Goup A (control group) in this group animals were injected with the normal saline intraperitoneally single daily dose for 30 days.
Group B injected intrapertioneally with cadmium chloride single daily dose 3.5 mg/kg body weight for 30 days.
Group C injected intraperetonially with cadmium chloride in a dose of 3.5 mg/kg body weight. Intragastric tube was put to recieve parsley oil in a dose of 0.5 ml/kg body weight prior to cadmium injection. The two drugs were given for 30 days.
Group D recieved 0.5 ml/kg body weight by intragastric tube of parsley oil for 30 days.
At the end of this experiement, the animals were sacrified the lungs were collected from all groups and prepared for light microscopical examination.
Histological changes were detected in cadmium chloride treated group in comparison with the control group including congestion, inflammatory cell infiltration, interstial pneumonia (decreased alveolar space), thickening of interalveolar septum and damge to the alveolar cells. All these changes were eliminated by giving parsley oil.