Open AccessMelanoma and Mastocytosis
Author(s) -
Aleksandra Vojvodić,
Tatjana Vlaskovic-Jovicevic,
Petar Vojvodić,
Jovana Vojvodić,
Mohamad Goldust,
Zorica Perić-Hajzler,
Dušica Matović,
Goran Šijan,
Nenad Stepić,
Uwe Wollina,
Massimo Fioranelli,
Van Thuong Nguyen,
Michael Tirant,
Torello Lotti
Publication year - 2019
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2019.772
Subject(s) - microphthalmia associated transcription factor , medicine , stem cell factor , proto oncogene proteins c kit , melanoma , transcription factor , cutaneous mastocytosis , cancer research , stat3 , haematopoiesis , neural crest , stem cell , systemic mastocytosis , immunology , mast cell , signal transduction , microbiology and biotechnology , biology , genetics , embryo , gene
There are numerous cases reports and studies confirming the enhanced incidence of melanoma among patients with mastocytosis, especially with systemic mastocytosis. These two diseases are arising from two different types of cells; melanoma arises from neural crest cells and mastocytosis from hematopoietic stem cells. But there are a lot of similarities between the two diseases. The most important and significant is the dependence of the growth factor receptor c‐KIT and c‐KIT ligand (stem cell factor) for their growth and development. Also, expression of the STAT3 (signal transducer and activator of transcription 3) and transcription factors MITF (microphthalmia‐associated transcription factor) make the connection between melanoma and mastocytosis.