Open AccessDetection of Cancer Stem Cells in Colorectal Cancer: Histopathological and Immunohistochemical Study
Author(s) -
Nour El Hoda S. Ismaiel,
Walid M. Sharaf,
Dina Omar Helmy,
Mona M. Zaki,
Manal Badawi,
Ahmed Soliman
Publication year - 2016
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2016.126
Subject(s) - medicine , cd44 , colorectal cancer , immunohistochemistry , cancer stem cell , pathology , metastasis , adenocarcinoma , cancer , stage (stratigraphy) , rectum , oncology , cell , biology , paleontology , genetics
Growing evidence supports the notion that the onset of tumorigenesis could occur through cancer stem cells (CSCs). These tumour cells show low proliferative rates, high self-renewal capacity, propensity to differentiate into active proliferating tumour cells & resistance to chemoradiotherapy thus, possibly causing local recurrences & metastasis formation. CD44 has been used as a marker to isolate CSCs from colorectal carcinoma (CRC).