Open AccessEffect of Dual Blockade of Renin-Angiotensin System on Proteinuria
Author(s) -
Eqerem Hasani,
Alma Idrizi,
Myftar Barbullushi
Publication year - 2013
Publication title -
open access macedonian journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 17
ISSN - 1857-9655
DOI - 10.3889/oamjms.2013.004
Subject(s) - medicine , blockade , proteinuria , renin–angiotensin system , creatinine , blood pressure , angiotensin converting enzyme , angiotensin receptor , urology , pharmacology , endocrinology , receptor , kidney
Aim: Aim of the study was the evaluation of the effect of dual blockade of the renin-angiotensin system (RAS) on proteinuria. Material and Methods: Sixty patients, included in the study, were treated with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker for a period of 3 months. Results: The dual blockade of RAS resulted with decrease of proteinuria, a slight increase of serum creatinine and was not associated with a lowering of blood pressure.Conclusion: Combined therapy with ACE-I and ARB results in a more complete blockade of the RAS than monotherapy. In proteinuric nephropathies it reduces significantly baseline proteinuria