Open AccessFactors associated with increased odds of sensorineural hearing loss in infants exposed to the Zika virus during pregnancy
Author(s) -
Erika J Verján-Carrillo,
Efrén Murillo-Zamora,
Gabriel Ceja-Espíritu,
José Guzmán-Esquivel,
Oliver Mendoza-Cano
Publication year - 2021
Publication title -
journal of infection in developing countries
Language(s) - English
Resource type - Journals
eISSN - 2036-6590
pISSN - 1972-2680
DOI - 10.3855/jidc.12623
Subject(s) - zika virus , medicine , sensorineural hearing loss , pregnancy , odds ratio , odds , hearing loss , obstetrics , audiology , virology , virus , biology , logistic regression , genetics
The Zika virus (ZIKV) infection in pregnant women has been associated with an increased risk of birth defects. We aimed to estimate the prevalence of sensorineural hearing loss (SNHL) in infants exposed to the ZIKV during their gestation and evaluate the factors associated with its increased odds.
Methodology: A cross-sectional study was performed from July 2016 to June 2019 in a Western state of Mexico and data from 61 infants that presented with laboratory-positive (RT-qPCR) evidence of in utero exposure to ZIKV were analyzed. Brain stem auditory evoked potentials were used.
Results: Hearing loss was documented in 6 (9.8%) of infants. The prevalence of SNHL in children with microcephaly was 75.0%, as compared to 5.3% in those without anomalies (odds ratio, OR = 14.31, 95% CI = 2.54 – 19.12). Half of children with SNHL had no physical manifestations of gestational ZIKV exposure.
Conclusions: Hearing loss was a frequent event in ZIKV-exposed children, particularly among those with microcephaly. Our results highlight the relevance of systematic hearing screening.