Open AccessEthnic Differences in Antipsychotic treatment responses in Early Intervention in Psychosis
Author(s) -
Nandini Chakraborty,
Shiraz Ahmed,
Hannah Booth,
Hawa Aswat
Publication year - 2021
Publication title -
the physician
Language(s) - English
Resource type - Journals
eISSN - 2732-5148
pISSN - 2732-513X
DOI - 10.38192/1.7.1.6
Subject(s) - ethnic group , antipsychotic , intervention (counseling) , medicine , olanzapine , psychosis , psychiatry , schizophrenia (object oriented programming) , clinical psychology , psychology , sociology , anthropology
Background
Ethnic variations in pathways to early intervention in psychosis (EIP) have been studied. However, it is important to explore the ethnic variations in response to pharmacological treatment in EIP.
Aims
To look at ethnic variation in response to antipsychotics.
Method
Electronic patient records in December 2018 were perused for:
Sociodemographic details including ethnicity
Prescribed antipsychotic and dosage to which the patient had responded
Results
White, Black and Asian ethnic groups responded mostly to Olanzapine. The largest proportion of the mixed ethnic group responded to Aripiprazole. The White and Asian groups showed the best responses to Lurasidone at 74 mg. There was a slight response in the mixed and other ethnic groups only at the higher dose of 111 mg. The medication has not been used with any benefit in the Black ethnic group.
Conclusion
The complex differences highlighted amongst ethnic responses to treatment make a case for multi-centric studies to further explore ethnic differences in early intervention treatments. This will help streamline offered treatments to maximise response in EIP.