Open AccessA Review on: “Recent Updates on Poly-Adp-Ribosylation (Parylation) in Physiology and Pathology”
Author(s) -
Pritam Paramguru Mahapatra,
Manaswini Giri
Publication year - 2020
Publication title -
international journal of innovative science and research technology
Language(s) - English
Resource type - Journals
ISSN - 2456-2165
DOI - 10.38124/ijisrt20may326
Subject(s) - nad+ kinase , poly adp ribose polymerase , adp ribosylation , parp1 , chemistry , covalent bond , ribose , dna , biochemistry , microbiology and biotechnology , biology , enzyme , polymerase , organic chemistry
One of the most common cellular responses to DNA breakage is the covalent post-translational modification of the nuclear proteins with poly ADP ribose from the NAD+ as a precursor, which is mostly catalyzed by the poly-ADP-ribose polymerase1(PARP1).