Open AccessResearch of the adsorption of aliphatic carboxylic acids on the surface of polysorb
Author(s) -
Alexander A. Kimyashov,
Alexander V. Syromolotov,
Maksim O. Pavlov
Publication year - 2020
Publication title -
butlerovskie soobŝeniâ
Language(s) - English
Resource type - Journals
ISSN - 2074-0212
DOI - 10.37952/roi-jbc-01/20-64-10-63
Subject(s) - adsorption , formic acid , chemistry , silanol , acetic acid , silicon dioxide , freundlich equation , diethylamine , organic chemistry , inorganic chemistry , carboxylic acid , silicon , chemical engineering , catalysis , engineering
The enterosorbent "Polysorb" is a highly dispersed powder of silicon dioxide. In medicine, it is used as a detoxifier for poisoning with organic substances and heavy metals. Recently, the direction in pharmaceuticals related to targeted delivery of medicines has begun to develop. One of the carriers of medicinal substances is highly dispersed silicon dioxide. There are explorations that show that with simultaneous oral administration of highly dispersed silicon dioxide and the antibiotic amphotericin, the concentration of the latter in the blood increases significantly. Recently, there have been studies showing that delivering propionic acid to the gut reduces fat accumulation in overweight people. The goal of this work is study the adsorption of aliphatic carboxylic acids, namely: formic, acetic, propionic on the surface of polysorb. Using electron microscopy, it was shown that polysorb powder consists of particles of different sizes and shapes. Their size varies from units to tens of micrometers. Adsorption isotherms of formic, acetic, and propionic acids were constructed at a temperature of 295 K. It is shown that they have an S-shaped character, therefore, adsorption is due to the formation of hydrogen bonds between the silanol groups of the hydrated POLYSORB and the carboxyl groups of acids. It is established that these isotherms are adequately described by the Freundlich model up to the saturation region. With an increase in the hydrocarbon radical, the adsorption capacity of acids decreases. The kinetics of acid adsorption on the polysorb surface was described using pseudo-first and pseudo-second order models. It was found that the adsorption kinetics of carboxylic acids is adequately described by the pseudo-first-order model. The time of onset of adsorption equilibrium is 30 seconds at a temperature of 295 K.