Open AccessAdsorption of antibiotics on hydroxyapatite
Author(s) -
Vladimir V. Grishin
Publication year - 2020
Publication title -
butlerovskie soobŝeniâ
Language(s) - English
Resource type - Journals
ISSN - 2074-0212
DOI - 10.37952/roi-jbc-01/20-63-7-92
Subject(s) - adsorption , aqueous solution , dispersion (optics) , chemical engineering , materials science , enamel paint , solvent , chemistry , composite material , organic chemistry , physics , optics , engineering
Hydroxyapatite has properties to sorb various substances. When examining the surface of the tooth enamel, the interaction of enamel hydroxyapatite with various medicinal substances was found. One of the main issues was the possibility of creating protective adsorption films on the tooth enamel to protect against bacterial insemination. These films in the experiment are kept for a short time and do not withstand the processes of eating. The adsorption process is reversible and no chemical interaction with hydroxyapatite was observed. Since the adsorption process takes place on the surface of crystals and is caused by physical-chemical interactions, an increase in the adsorption surface can lead to the accumulation of a medicinal substance in the weight unit of the base. The experiments performed on dispersed hydroxyapatite showed the perceptivity of this area, but it was necessary to increase the dispersion of crystals Mechanical and physical-chemical methods did not help to achieve the results. Chemical method for obtaining hydroxyapatite in an aqueous solution was chosen as an optimal one. Chemical synthesis of nanocrystalline hydroxyapatite was performed. Hydroxyapatite without additional purification and isolation was forced to interact with a solution of the appropriate antibiotic. To control the interaction process, a spectrophotometric method of analysis in the ultraviolet range was chosen. Conducted studies of the interaction of hydroxyapatite with antibiotics by spectrophotometric method showed a change of the products of interaction of a suspension of hydroxyapatite with an antibiotic solution compared to the spectrum of the original antibiotic in the spectra in the ultraviolet range. Biological activity was tested on a culture of Staphylococcus aureus in comparison with a pure antibiotic. In comparison with a pure antibiotic, its complex with hydroxyapatite showed a delayed effect, but did not change the nature of the antibiotic in relation to the microorganism.