Open AccessPerspective of delayed Hypersensitivity: A review
Author(s) -
Nnodim Johnkennedy,
Njoku-Obi Treasure,
Hauwa Bako
Publication year - 2022
Publication title -
journal la medihealtico
Language(s) - English
Resource type - Journals
eISSN - 2721-1231
pISSN - 2721-1215
DOI - 10.37899/journallamedihealtico.v3i2.623
Subject(s) - hypersensitivity pneumonitis , immunology , medicine , hypersensitivity reaction , delayed hypersensitivity , cd8 , antigen , allergy , inflammation , contact dermatitis , infiltration (hvac) , lung , physics , thermodynamics
T cells enter tissues and are activated by antigen-presenting cells to produce cytokines that cause inflammation in the local area. In allergic contact dermatitis, drug eruptions, asthma, and autoimmune disorders, CD8+ T lymphocytes mediate DTH reactions. As an example of this type IV hypersensitivity, chronic DTH reactions, contact hypersensitivity, and hypersensitivity pneumonitis are all examples. Infiltration of an antigen-exposed region by Th1 cells and macrophages, which inflict tissue damage, is the primary cause of the delayed onset of symptoms. It has thus been outlined that this delayed hypersensitivity reaction.