Open AccessVITILIGO – FROM CLINICAL MANIFESTATIONS TO PATHOPHYSIOLOGICAL MECHANISMS AND CELL DEATH
Author(s) -
Ana Maria Chivu,
Elena Bălăşescu,
Roxana Ioaedelcu,
Alice Brînzea,
Mihaela Antohe,
Anastasia Coman,
Gabriela Turcu,
Ionela Hulea,
Daniela Adriana Ion
Publication year - 2021
Publication title -
romanian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2069-606X
pISSN - 1220-5478
DOI - 10.37897/rmj.2021.2.3
Subject(s) - vitiligo , genetic predisposition , disease , medicine , pathophysiology , pathogenesis , endocrine system , immune system , immunology , oxidative stress , programmed cell death , dermatology , pathology , biology , genetics , hormone , apoptosis
The pathogenesis of vitiligo is still unclear. The complexity of the disease seems to be based on the intervention of environmental factors in the background of genetic predisposition which will determine the response of the immune system, the involvement of the nervous and endocrine systems, altered metabolisms and increased oxidative stress - all these elements leading to melanocytic dysfunction and their subsequent destruction. Melanocytic death has a clinical correspondent that embraces the form of white macules on the skin, associated or not with leucotrichia. A better understanding of vitiligo' s pathophysiology and mechanisms of cell death at the skin level can be a step to some appropriate treatment strategies.