Open AccessNitric oxide in the pathogenesis of alcoholic liver disease
Author(s) -
Ruxandra Deliu,
Ionuț Donoiu,
Tudorel Ciurea,
Universitatea de Medicină şi Farmacie Disciplina Cardiologie,
Universitatea de Medicină şi Farmacie Disciplina Gastroenterologie
Publication year - 2016
Publication title -
romanian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2069-606X
pISSN - 1220-5478
DOI - 10.37897/rmj.2016.2.5
Subject(s) - nitric oxide , pathogenesis , alcoholic liver disease , alcoholic hepatitis , cirrhosis , liver disease , medicine , disease , fatty liver , liver injury , steatosis , ethanol , gastroenterology , chemistry , biochemistry
Alcoholic liver disease is the most common condition associated with ethanol consumption and includes three forms of injury with gradually increasing severity: hepatic steatosis, alcoholic hepatitis and cirrhosis. The complex pathogenesis of this disease includes endothelial dysfunction which comprises as central factor nitric oxide. Synthesis of nitric oxide by the three types of nitric oxide synthases is modulated by many factors with pathogenic and potentially therapeutic implications in alcoholic liver disease.