Open AccessPotential markers for allergic rhinitis evaluation
Author(s) -
Adina ZamfirChiruAnton,
Bucureşti Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“,
Dan Cristian Gheorghe,
Bucureşti Spitalul Clinic de Urgenţă pentru Copii „M.S. Curie“
Publication year - 2016
Publication title -
romanian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2069-606X
pISSN - 1220-5478
DOI - 10.37897/rmj.2016.1.4
Subject(s) - mucous membrane of nose , immunology , immune system , medicine , inflammation , extracellular matrix , matrix metalloproteinase , fibrosis , pathology , proteases , mast cell , biology , biochemistry , enzyme , microbiology and biotechnology
Allergic rhinitis is the result of a permanent/intermitent inflammation of the nasal mucosa, exposed to certain alergens. An immunological reaction is the fundamental cause – a type I hypersensitivity reaction, followed by local inflammatory response and immune cell pooling (eosinophiles, basophiles, Th cells, mast cells) in the nasal mucosa. Matrix metaloproteinases are tissue proteases that degrade extracellular matrix and basilar membrane and modulate immune responses. Our article reviews the part metalloproteinases play in the changes suffered by the nasal mucosa in chronic allergic rhinitis (fibrosis, metaplasia, edema, inflammatory cell infiltration).