Open AccessSERONEGATIVE ANTIPHOSPHOLIPID SYNDROME
Author(s) -
Manole Cojocaru,
Inimioara Mihaela Cojocaru,
B Chicoş,
I Stoia,
Carol Davila,
G Marinescu
Publication year - 2015
Publication title -
romanian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2069-606X
pISSN - 1220-5478
DOI - 10.37897/rmj.2015.1.4
Subject(s) - antiphospholipid syndrome , medicine , thrombosis , venous thrombosis , immunology , antibody
Seronegative antiphospholipid syndrome (seronegative APS) has remained an enigma and the concept is controversial. A small group of APS patients remain persistently negative for routine assays of antiphospholipid (aPL) antibodies. The clinical features are well defined, and include the tendency to both arterial and venous thrombosis, to recurrent miscarriages, and to occasional thrombocytopenia. Patients with clinical manifestations highly suggestive of APS but persistently negative conventional aPLs are classified as having seronegative APS.