Open AccessCOULD ANTI-SYNTHETASE SYNDROME BE A GOOD PREDICTOR FACTOR FOR INTERSTITIAL LUNG DISEASE?
Author(s) -
Sineta Cristina Firulescu,
Paulina Lucia Ciurea,
Cristina Dorina Pârvănescu,
Beatrice Andreea Chisălău,
Andreea Lili Bărbulescu,
Cristina Criveanu,
Adina Turcu-Ştiolică,
Roxana Edmee Mustafa,
Florentin Ananu Vreju
Publication year - 2017
Publication title -
romanian journal of rheumatology
Language(s) - English
Resource type - Journals
eISSN - 2069-6086
pISSN - 1843-0791
DOI - 10.37897/rjr.2017.2.9
Subject(s) - interstitial lung disease , myositis , antibody , medicine , myopathy , immunology , disease , rheumatoid arthritis , phenotype , lung , pathology , biology , genetics , gene
Anti-synthetase syndrome (SAS) is an autoimmune inflammatory myopathy, whose immune profile is dominated by anti-RNA synthetase antibodies (ARS), with a specific clinical phenotype. The major diagnostic criteria of SAS include the triad of myositis, arthritis and interstitial lung disease (ILD), on the background of positive anti-ARS antibodies. ILD in SAS, has a good evolution compared to the one in PM/DM, due to protective presence of anti Jo-1 antibodies.