Open AccessDevelopment study of new topical formulations with erythromycin
Author(s) -
Lacramioara OCHIUZ,
Andreea Crețeanu,
Manuela Hortolomei,
Cătălina Anişoara Peptu,
Iulian Stoleriu,
Marcel Popa,
Cristian PEPTU
Publication year - 2017
Publication title -
romanian journal of pharmaceutical practice
Language(s) - English
Resource type - Journals
eISSN - 2069-6671
pISSN - 2066-5563
DOI - 10.37897/rjphp.2017.3.1
Subject(s) - erythromycin , solubility , chemistry , cyclodextrin , dosage form , pharmacology , chromatography , antibiotics , organic chemistry , biochemistry , medicine
Erythromycin is a macrolide antibiotic prescribed for the topical treatment of acne. Pharmacologically, erythromycin has the disadvantage of being poorly soluble in water. This leads to formulation challenges in semisolid dosage forms. In recent years, many published studies have shown the ability of cyclodextrins to form complexes with drugs. These new complexes are characterized by much improved solubility and permeation compared to the „parent“ molecule. The aim of this study was to synthesize an inclusion complex of erythromycin and lactide-β-cyclodextrin for the formulation of semisolid bases and the development of innovative topical preparations with erythromycin. The erythromycin-lactide-βcyclodextrin complex was characterized by scanning electron microscopy and Fourier-transform infrared spectroscopy. Semisolid formulations were pharmacologically evaluated by in vitro dissolution test and kinetic analysis of drug release by fitting to representative mathematical models. The results obtained showed a prolonged release of erythromycin from erythromycin-lactide-β-cyclodextrin formulations and a higher permeability coefficient of these formulations compared to the erythromycin-based release.