Open AccessDiagnostic biomarkers of multiple sclerosis
Author(s) -
Mohammad Asgharzadeh,
Mir Reza Valiallahzadeh,
Zahra Taghinejad,
Behroz Mahdavi Poor,
Hossein Samadi Kafil,
Vahid Asgharzadeh,
Jalil Rashedi
Publication year - 2021
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2021.4.2
Subject(s) - multiple sclerosis , human leukocyte antigen , disease , immunology , immune system , myelin , medicine , virus , antibody , interferon , central nervous system , antigen , biology , pathology
Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system (CNS) that is common in people between the ages of 20 and 40. Although the exact cause of MS is still unknown, evidences shows that genetic and environmental factors have a role in activating immune cells to attack the myelin sheath of the neurons, and causing them to be damaged. In order to control and reduce the disease prevalence, early identification of at risk people and patients in the early stages of the disease is important. Measurement of interferon gamma (IFN-γ), vitamin D, melatonin, neurofilaments, micro RNA-132 (miR-132), miR-155, determination of antibody titer against Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) typing are appropriate methods to diagnose the disease, and ultimately prevent its recurrence.