Open AccessPEGINTERFERON-ALPHA 2A RELATED PERIPHERAL NEUROPATHY: A CASE REPORT AND REVIEW OF THE LITERATURE
Author(s) -
Amalia Ghergu,
Alexandra Oprişan,
Cristina Mitu,
S Popescu,
Oana Morari
Publication year - 2017
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2017.3.7
Subject(s) - discontinuation , medicine , peripheral neuropathy , weakness , chronic hepatitis , surgery , pediatrics , virus , immunology , diabetes mellitus , endocrinology
We report the case of a 46-year old female with chronic hepatitis C virus infection who developed paresthesia and weakness of face and upper and lower extremities nine months after administration of peginterferon-alpha 2a. Considering her clinical evolution, neurological examination and nerve conduction studies, she was diagnosed with multifocal motor neuropathy related to peginterferon-alpha treatment. The patient recovered after use of intravenous immunoglobulins. From our knowledge there is no data in the literature about multifocal motor neuropathy related to peginterferon-alpha treatment. Doctors should be aware of this rare association, which requires immediate drug discontinuation and early management.