Open AccessANTIOXIDANT EFFECT OF FLAVONOIDS IN NEURODEGENERATIVE DISEASES
Author(s) -
Adriana Elena Bulboacă,
Cluj-Napoca Pharmacy,
Sorana S. Bolboaca,
Ioana Stănescu,
Carmen A. Sfrângeu,
Angelo Bulboacă
Publication year - 2017
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2017.2.2
Subject(s) - neurodegeneration , oxidative stress , reactive oxygen species , antioxidant , reactive nitrogen species , parkinson's disease , neuroscience , neuroprotection , biology , chemistry , pharmacology , disease , medicine , biochemistry
The investigation of the mechanisms that leads to neuronal apoptosis is under investigation all over the world. The enhancement of oxidative stress in brain neurons is one of the most important pathophysiological mechanism associated with neurodegeneration. The antioxidant effect of flavonoids can be one important mechanism for modulation of neuronal apoptosis in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. In addition to their influence on the cerebral blood flow, flavonoids interact with signalization cascades that lead to the inhibition of neuronal death by oxidative stress apoptosis and thus promote neuronal survival and synaptic plasticity. Acting on the intracellular antioxidant mechanisms the flavonoids can become a balance regulator for production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Addition of antioxidant effect of flavonoids to dietary components can constitute an adjuvant therapy for delaying the neurodegenerative processes. The aim of this paper was to review the antioxidant effects of flavonoids in Alzheimer’s and Parkinson’s diseases.