Open AccessINFLUENCE OF PRE-SYMPTOMATIC AND SYMPTOMATIC STAGES OF PARKINSON’S DISEASE AND ITS TREATMENT UPON CHANGES OF VARIABILITY OF CARDIAC RHYTHM
Author(s) -
М.Л. Мамалыга,
Л. М. Мамалыга
Publication year - 2017
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2017.1.2
Subject(s) - medicine , parkinson's disease , dopaminergic , stage (stratigraphy) , disease , heart rate , cardiology , rhythm , heart rate variability , neurotoxin , dopamine , autonomic nervous system , blood pressure , paleontology , biology
The aim of the study was to determine the influence of pre-symptomatic and symptomatic stages of Parkinson’s disease and its treatment on the cardiac disorders in C57BL/6 mice. Materials and methods. Investigations were carried out on C57BL/6 male mice. Degeneration of dopaminergic neurons were created by the neurotoxin. In freely moving animals in online regime a 24-hour ECG recording using wireless telemetry system ML880B106 was conducted. After completing studies animals was injected L-dopa (a precursor of dopamine synthesis). All the animals underwent repeated study of HRV. Results. The disbalance of autonomic heart regulation develops already in the pre-symptomatic stage of Parkinson’s disease. The early symptomatic stage is accompanied by the aggravation of heart dysfunction due to the shift of the autonomic balance towards the increase of sympathetic and decrease of parasympathic effect on the heart. Coronary disorders concomitant to Parkinson’s disease increase a risk of life threatening arrhythmia and sudden death syndrome not only in the early symptomatic stage but also in the pre-symptomatic stage. Conclusions. L-dopa effectively restores the structure of heart rate and prevents the risk of life threatening arrhythmia only in the pre-symptomatic stage of disease.