Open AccessINHERITED THROMBOPHILIA SECONDARY TO PROTEIN S DEFICIENCY ASSOCIATED WITH ISCHEMIC STROKE. CASE REPORT
Author(s) -
Diana Matcau,
Pharmacy Timisoara,
Claudia Bârsan,
Traian Flavius Dan,
Camelia Barbusi,
Any Docu Axelerad,
Dragoș Cătălin Jianu,
Constanta Pharmacy
Publication year - 2016
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2016.4.8
Subject(s) - thrombophilia , medicine , protein c deficiency , protein s deficiency , magnetic resonance angiography , stroke (engine) , angiography , thrombus , radiology , thrombosis , magnetic resonance imaging , venous thrombosis , cardiology , surgery , mechanical engineering , engineering
Thrombophilia is characterized by an increased tendency to arterial and venous thrombus formation. Inherited thrombophilia can be secondary to protein S deficiency. Concomitant use of oral contraceptive pills increases the risk of venous thromboembolism and arterial thrombosis. We report a case of a 34-year-old female who used oral contraceptive pills for many years, who developed acute ischemic stroke of right occipital lobe with secondary left superior homonymous quadrantanopia. We have run several tests to establish the ischemic stroke etiology: unenhanced brain and cervical spine computed tomography, brain magnetic resonance imaging and magnetic resonance angiography (including MR venography), computed tomographic angiography, echocardiography, extracranial duplex ultrasound and laboratory data (including thrombophilia testing). The laboratory investigations confirmed that the ischemic stroke of our patient resulted from a severe inherited thrombophilia secondary to protein S deficiency.