Open AccessNATURAL AND SYNTHETIC DYE COMPOUNDS: APPLICATIONS IN GLIOBLASTOMAS THERAPY
Author(s) -
Oana Alexandru,
Ada Maria Georgescu,
Laurențiu Ene,
Valerica Tudorică,
Anica Dricu
Publication year - 2015
Publication title -
romanian journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 4
eISSN - 2069-6094
pISSN - 1843-8148
DOI - 10.37897/rjn.2015.2.2
Subject(s) - angiogenesis , in vivo , medicine , cancer research , glioblastoma , biology , microbiology and biotechnology
Glioblastomas are the most aggressive high-grade gliomas, characterized by diffuse infiltrative growth, high migration potential, angiogenesis, predisposition for necrosis that are decisive steps in resistance to therapy. In spite of current advances, the treatment of these tumors remains a challenge for oncologists. Because of the poor prognosis of these patients, development and testing of more effective therapeutic strategies is undertaken by several medical scientific communities. One of the new classes of drugs that are tested in vivo and in vitro is represented by the dye-compounds. This review focuses on efficacy of these drugs and their mechanisms of action in glioblastomas.