Open AccessCorrelation between cervical excisional procedures and the risk of preterm birth in subsequent pregnancies
Author(s) -
Cezara Diana MUGESCU,
Brînduşa Ana Cimpoca-Raptis,
Anca Marina Ciobanu,
Radu Botezatu,
Corina Gică,
Gheorghe Peltecu,
Anca Maria Panaitescu,
Nicolae Gică
Publication year - 2021
Publication title -
romanian journal of medical practice
Language(s) - English
Resource type - Journals
eISSN - 2069-6108
pISSN - 1842-8258
DOI - 10.37897/rjmp.2021.s3.5
Subject(s) - medicine , cervical conization , obstetrics , dysplasia , pregnancy , risk factor , gynecology , cervical cancer , cervical intraepithelial neoplasia , cancer , biology , genetics
Cervical excisional procedures stand as an important risk factor for preterm birth (PTB) in subsequent pregnancies in various articles in the medical literature. We performed an evidence-based review of the obstetrical outcomes succeeding excisional procedures for cervical dysplasia as follows: we reviewed 16 studies published between 2015 and 2020 that assessed whether there is an association between excisional cervical procedures and unfavorable obstetrical outcomes. Nevertheless, there are several other aspects of the problem, taken into account as possibly responsible for increasing the risk of PTB, as the grade of the dysplasia, the effect of depth/length/volume of the excised cone specimen, prophylactic procedures for the prevention of PTB, age, interval conization-pregnancy. The majority of the authors suggested an association between excisional procedures and preterm birth or other obstetrical events. However, some of them did not find statistically significant data in order to strongly affirm a correlation between conization and PTB, or, on the contrary, disproved the given hypothesis. There is no consensus regarding cervical excisions as being an individual risk factor for PTB, therefore more studies need to be conducted in order to come to a strong, universal conclusion.