Open AccessIntrahepatic cholestasis of pregnancy
Author(s) -
Ana Maria Scutelnicu,
Brînduşa Ana Cimpoca-Raptis,
Anca Marina Ciobanu,
Nicolae Gică,
Radu Botezatu,
Corina Gică,
Gheorghe Peltecu,
Anca Maria Panaitescu
Publication year - 2021
Publication title -
romanian journal of medical practice
Language(s) - English
Resource type - Journals
eISSN - 2069-6108
pISSN - 1842-8258
DOI - 10.37897/rjmp.2021.s3.11
Subject(s) - cholestasis of pregnancy , medicine , ursodeoxycholic acid , pregnancy , obstetrics , cholestasis , asphyxia , amniotic fluid , etiology , bile acid , meconium , fetus , adverse effect , gastroenterology , biology , genetics
Intrahepatic cholestasis of pregnancy is the most common liver disease during pregnancy. The main features are maternal pruritus, in the absence of a rash, and raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including preterm birth, meconium-stained amniotic fluid, fetal asphyxia with neonatal unit admission or even stillbirth. The main treatment option is ursodeoxycholic acid. We review the etiology, diagnosis, adverse pregnancy outcomes, focusing especially on management of this intriguing condition.