Open AccessPrediction risk of complications and death in children with chronic hepatitis infection and extrahepatic manifestations
Author(s) -
Alice Azoicăi,
I Popa,
Evelina Moraru,
Iaşi Spitalul Clinic de Urgenţe pentru Copii „Sf. Maria“
Publication year - 2015
Publication title -
romanian journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 2069-6051
pISSN - 1454-3389
DOI - 10.37897/rjid.2015.2-3.9
Subject(s) - medicine , cirrhosis , etiology , ascites , encephalopathy , gastroenterology , hepatic encephalopathy , population , itching , hepatitis , pediatrics , surgery , environmental health
Background. Cirhogenetic chronic evolution of these patients is related to the etiology, co-morbidities, the type of virus, the addition of metabolic diseases. Fibrosis markers of biological and clinical aspects must be permanently monitored. Materials and method. In a retrospective study we followed 40 patients diagnosed with cirrhosis, in the IInd Pediatric Clinic of the „Sf. Maria“ Emergency Hospital for Children in Iasi, between 2004-2014, out of 239 cases chronically infected recorded in this period of time. Results. The analysis of patients with extrahepatic manifestations showed no statistically significant differences, although the lack of seroconversion is more frequent in patients with extrahepatic manifestations versus those without (31.42% vs. 22.18%). The prospective study conducted in the pediatric population that was followed demonstrated that the risk of liver cirrhosis is by 3.03 times higher in male patients. The average age was 12.88 years, most children were diagnosed with liver cirrhosis after 10 years of age. The etiology predominant predisposing to development was HBV hepatitis, unlike hepatitis metabolic type, which has a milder trend. Conclusion. Complications detected included portal hypertension, ascites, pruritus, hepatic encephalopathy. In terms of frequency, itching had the largest share, followed by hepatic encephalopathy.