Open AccessRenoprotective effects of nicotine
Author(s) -
Corina Daniela Ene,
Mircea Penescu,
Ilinca Nicolae,
Emanoil Ceauşu
Publication year - 2015
Publication title -
romanian journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 2069-6051
pISSN - 1454-3389
DOI - 10.37897/rjid.2015.2-3.1
Subject(s) - nicotine , ischemia , hypoxia (environmental) , limiting , alkaloid , pharmacology , inflammation , cholinergic , medicine , kidney , biology , immunology , chemistry , mechanical engineering , botany , organic chemistry , oxygen , engineering
Several recent data showed the protective effect of nicotine in cells metabolism and in limiting ischemic and reperfusion lesions in kidney. These effects of nicotine are the results of the interaction between nicotine and cholinergic receptors, expressed in many cells and tissues in the organism. Nowadays, the therapeutic options in reducing the effects of hypoxia, ischemia and reperfusion are limited. In this paper, we will present the newest data about the role of nicotine in limiting inflammation and preventing the effects of tissue hypoxia and ischemia. These optimistic results justify the researches regarding the possible therapeutic effects of nicotine, a natural alkaloid that plays an essential role in adjusting the production of cytokines and the antiinflamatory response.